
By Timothy G. Tyler, PharmD, FCSHP
Director, Pharmacy Services, Comprehensive Cancer Center at Desert Regional Medical Center, Palm Springs, CA
Breast Cancer Awareness Month is a good time to celebrate the advances in breast cancer diagnosis and treatment that have driven survivorship rates to levels not seen before.
This significant decline in mortality rates owes as much to pharmacology as it does to early screening and diagnosis.Central to these advances is the development of numerous drugs in recent years. Groundbreaking treatments have transformed breast cancer from the death knell it once was to a disease that can be managed for many years.
Potential drug interactions in metastatic breast cancer patients
But a significant issue has emerged in this otherwise hopeful landscape. The same pharmacological advances increase the potential for drug interactions, adding a layer of complexity when attempting to customize regimens for individual patients. In fact, an estimated 20-30% of adverse drug reactions result from drug interactions. Patients receiving multiple drug regimens are particularly at risk. Although commonly thought to occur between two pharmacological agents, drug interactions may involve concurrent prescription drugs, over-the-counter drugs, excipients used in drugs, herbal medications, food products or environmental factors like cigarette smoke.